Last night during the first Republican presidential debate of the 2016 election cycle in Ohio, leading candidate Donald Trump took the time to diss longtime nemesis Rosie O'Donnell. "You've called women you don't like 'fat pigs,' 'dogs,' 'slobs,' and 'disgusting animals'" debate moderator Megyn Kelly said to Trump. Before Kelly had a chance to even finish asking the question, he interrupted and held up his pointer finger as he prepared to speak. "Only Rosie O'Donnell," Trump said as the crowd loudly cheered.

Kelly however was not going to give up on her question that quickly. The Fox News correspondent pointed out that "for the record, it was well beyond Rosie O'Donnell," to which Trump snickered back, "Yes, I'm sure it was."

Kelly continued on, pointing out that Trump has posted negative comments about women's looks on Twitter and has made similar statements on his reality show, "Celebrity Apprentice."

"I've been challenged by so many people and I don't frankly have time for total political correctness," he said, according to CBS News. "This country is in big trouble. We don't win anymore."

Minutes after Trump made his dig at O'Donnell, the comedian indirectly replied to him on Twitter.

"Try explaining that 2 ur kids," she wrote.

This is hardly the first time the two have butted heads.

"She's an extremely unattractive person who doesn't understand the truth. ... I think she's a terrible person ... She has failed at everything she has done... She's a bully and she sucker punches people," he once said on "Larry King Live," according to USA Today.

"Probably the Trump stuff was the most bullying I ever experienced in my life, including as a child," O'Donnell told People in 2014. "It was national, and it was sanctioned societally. Whether I deserved it is up to your own interpretation."