Showtime's "Nurse Jackie" will work its final shift.

The network announced Wednesday that the twisted comedy series, starring Edie Falco as Jackie Peyton, will end its TV run with a seventh and final season, according to The Hollywood Reporter.

"#NurseJackie is working one last shift!" the network tweeted. "Join us in celebrating and bidding farewell to the 7th and FINAL season in 2015."

"It is with great sadness and pride that we and Showtime bid farewell to such an outstanding series like Nurse Jackie, its stellar cast led by the incomparable Edie Falco, brilliant producing team led by Clyde Phillips and Richie Jackson, and the entire Nurse Jackie family of craftspeople and artists that bring this show to rapt audiences year after year," said Kevin Beggs, Lionsgate Television chairman. "We consider ourselves lucky to have been part of the Nurse Jackie story and look forward to an unforgettable final season."

"Nurse Jackie" premiered in 2009 and centers around a highly skilled nurse who has an addiction to painkillers and is trying to work on her relationships with people.

The show has won five Emmy Awards, a Humanitas Prize, an AFI Award for "Outstanding Television Program" and several Prism Awards for its depiction of substance abuse.

Falco won an Emmy for best actress in a comedy, making her the only actress to win the lead acting Emmy Awards in both comedy and drama. The actress previously won an Emmy for her drama role in HBO's "The Sopranos."

"Edie is one of our finest actresses," David Nevins, Showtime president, said in an announcement. "We are so honored to have had her on the network. She creates indelible characters and Nurse Jackie Peyton is no exception. I know this final season will bring her story to a close that will satisfy the ever-growing number of loyal viewers who have been entranced and, at times, appalled by Jackie through the years. I want to thank Edie, the incredible cast of 'Nurse Jackie' and Clyde Phillips and Richie Jackson who have led the show to the success that it is today."

"Nurse Jackie" also stars Merritt Wever, Paul Schulze, Dominic Fumusa, Anna Deavere Smith, Stephen Wallem, Ruby Jerins and Mackenzie Aladjem. Its final season becomes the first without co-star Peter Facinelli as a series regular, but he will appear in some capacity on the show.

Its final season will also feature Tony Shalhoub ("Monk") in a guest-starring role.