Buffalo Bills running back LeSean McCoy is unlikely to play this Sunday against the New York Giants, as he is recovering from a hamstring injury, according to NFL reporter Rand Getlin.

McCoy has struggled this season in Buffalo and has not seen the end zone through three games. McCoy is averaging just 3.4 yards per carry, but has only seen a limited number of touches. The Bills received McCoy through a trade with the Philadelphia Eagles this past March. Last season, in Philadelphia, McCoy rushed for 1,319 yards with five touchdowns. Whether it's the style of offense or McCoy's hamstring injury, he doesn't seem to have the same step this year.

Running back Karlos Williams will likely pick up the load this weekend, but it's not anything new for the rookie back. Williams has scored in every game so far this season, and last week against the Miami Dolphins, he rushed for 110 yards on just 12 carries. The Bills are 2-1 after three games this season and Williams has been a big part of that. If Williams continues to play like this, he may earn himself the starting role eventually. Many think Williams will be able to carry the load with McCoy out, and he will have a good chance to prove himself this weekend against the Giants.

Bills wide receiver Sammy Watkins is reportedly dealing with a calf injury, according to NFL reporter Ian Rapoport. That likely means the Bills will try to take the Giants on the ground this weekend, and Williams will likely be leading the way. The Giants have the second best rush defense in the league after three games, but it's still early in the season and Williams will try to pick up where he left off Sunday.