Chelsea Handler bid farewell to the E! Network in the final episode of “Chelsea Lately” on Tuesday.

Handler went out with a bang, inviting many of her favorite celebrities to help her say goodbye. Sandra Bullock, Jennifer Aniston, Vanessa Hudgens, Wiz Khalifa, Gerad Butler, Gwen Stefani, Miley Cyrus, 50 Cent and Selena Gomez were amongst many of Handler’s former guests that stopped by.

Aniston and Bullock helped stage a fake intervention for Handler, claiming Netflix was actually code for rehab for her “drinking issues.” Ellen DeGeneres also stopped by for a shower scene skit with Handler, giving the viewers a few good laughs.

Handler also addressed her past with ex-boyfriend, rapper 50 Cent, who performed to the show’s live audience. The rapper teased Handler, asking her if she had gotten over their failed relationship. Handler responded with a few off-the-cuff remarks, claiming there’s no bad blood between them.

“I did end our relationship abruptly,” Handler told 50 Cent during the show. “I wanted you to know I have not dated a black man since.”

The rapper was flattered by the comment, but Handler didn’t end it there.

“They say when you go black you can’t go back well I came running back,” Handler said.

However, the late night show host ended her run on a more serious note, thanking the fans for helping make her show successful and the E! network. She also encouraged her audience to donate to Miley Cyrus’ new charity, which aims to get homeless youth off the streets.

"I never really got a good chance to be serious and say 'thank you' and I want you to know that I am grateful for this career, thank you very much." Chelsea told her viewers. "…Thank you to my family and mom. I hope you're watching me! I'll see you on Netflix!"