A team including three astronauts set their foot this Saturday midnight, following a 115 day mission in the International Space Station.

The team including three astronauts from the United States, Japan and Russia landed safely in Kazakhstan after a successful period of three months.

The Russian mission control central confirmed the safe landing of NASA's Kate Rubins, Roscosmos' Anatoly Ivanishin and Takuya Onishi of the Japan Aerospace Exploration Agency at 11.58pm EDT.

Rubins from the team of NASA comes with a degree in molecular biology and therefore, became the first individual to sequence DNA that too in space. As part of her latest expedition, she contributed much of her professional knowledge to numerous new studies at the International Space Station.

The landing took place Sunday morning near Dzhezkazgan as the Russian Soyuz space capsule with 49 crew members on the board returned to the Central Asian plains. The weather conditions were deemed clear along with a frosty atmosphere after the flight took off from orbital lab.

"Landing has taken place!" Russian mission control stated, with commentators on Nasa TV noting that the Soyuz craft had landed in an upright position.

It was Rubins and Onishi's first mission to the space, while flight commander Ivanishin was comparatively experienced as he went through a five month mission at the International Space Station five years ago.

"Everybody is feeling wonderful," said Ivanishin, who was the first one to come out of the craft.

Their space odyssey marks the first complete successful mission assisted by the orbital lab with a new generation of Soyuz spacecraft alongside new features and an upgraded system.

However, the team's arrival at the ISS was delayed by the time of two weeks as Russian space officials carried out further software tests and experiments on the upgraded Soyuz MS- 01 spacecraft.

Regardless, the participation of Rubins in the latest space mission program was a new initiative. NASA allowed the molecular biologist to sequence DNA aboard the International Space Station, which has never been performed before.

According to NASA, the biomolecule sequence in space can assist in identifying dangerous microbes and can also render a panacea for illness in space.

Rubins' professional insight is supposed to bolster soon after her flight in space. She is the first woman after Italian Samantha Cristoforetti to return earth after enduring the longest single space flight by a woman.

In terms of future space missions, NASA's most experienced female astronaut Peggy Whitson will join an all-male crew on board. It's supposed to be commenced on 17 November along with French astronaut Thomas Pesquet and Russian cosmonaut Oleg Novitskiy.