Jennifer Aniston and Chelsea Handler both had harsh words against Angelina Jolie in the late night show on Wednesday 21. Certainly, Aniston was expected to respond on her ex-husband's divorce but it came from Handler.

The 41-year-old comedian Handler said, "Brad and Angelina always said they wouldn't get married until everyone could get married...And I always said I wouldn't get married until they got divorced, so I'm officially accepting proposals. I'm ready."

Handler spoke on rumors that part of the problem was that Brad was allegedly drinking and smoking too much weed. She said, "I wonder why he would need to self-medicate? Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon instead of being stuck in a house with 85 kids speaking 15 different languages. Oh yeah, because he married a f--king lunatic, that's why."

Aniston, 47 has mostly taken the high road on all things Jolie,41 and Pitt, 52, keeping a dignified silence on their relationship that first began infamously on the set of their now iconic spy thriller "Mr. & Mrs. Smith" in 2004. Pitt was still married to Aniston at the time of the movie. They quietly tied the knot in August 2014 at their estate in France, reported the Sydney Morning Herald.

Brangelina's divorce was the perfect opportunity for Handler to speak out, confirming that she was on the side of Aniston. She hinted that she has still got more to say on their divorce.

"But we should all respect their privacy during this very difficult time," she said. "So this will be the last time I speak of this on TV. You can follow me on Twitter."

According to Us Weekly's report Aniston said "it's karma for you," when she heard about the Jolie-Pitt demise. Watch the video.