Is there something different about Khloé Kardashian's face? In a brand new clip from the next episode of "Keeping Up with the Kardashians," Kourtney and Kim Kardashian call their sister to confront her about her smile and how it has changed.

"Khloe, I was gonna call you and talk to you last night about this," Kim said to Khloé on the phone as her friend Jonathan Cheban looked on. "Your whole face has changed. Did you do any filler?"

"No, I haven't!" Khloé told her sisters.

Kim then continued to question Khloé about her face and flat out asked if she had gotten any Botox.

"No!" Khloé insisted.

"Khloe, your whole face changes when you laugh. It's like, I stare at you," Kim said before she asked Kourtney if she had noticed.

"Yes!" Kourtney laughed.

"I thought she was on drugs," Kim said. "It's like her whole gums and teeth."

Kourtney could not contain her laugher during the entire conversation. At one point, she even took out her phone to show Cheban a picture of Khloé to prove their point.

Sunday's episode of "Keeping Up with the Kardashians" is the season 11 final and will feature the highly anticipated birth of Kim and Kanye West's second child, Saint West. Since Saint was born in December 2015, he has not been photographed and has yet to make his TV debut.

The season 11 finale of "Keeping Up with the Kardashians" airs Sunday at 9 p.m. on E!

Check out the clip of Kourtney and Kim making fun of Khloé's face below: