Both the Buffalo Bills and the Washington Redskins will be without key offensive weapons for their respective teams Sunday.

Bills running backs LeSean McCoy and Karlos Williams have both been ruled out, and the Redskins will be without wide receiver DeSean Jackson and tight end Jordan Reed, according to NFL reporter Michael Fabiano.

The Bills will look to Boobie Dixon to take over the load this weekend at running back. Dixon has carried the ball eight times for zero yards this season, and will likely improve his numbers this weekend. Last season, Dixon rushed for 432 yards, and averaged 4.1 yards per carry. With McCoy likely out for a while with a hamstring injury, Dixon will look to get plenty of touches.

Karlos Williams has been an explosive player for the Bills, but the rookie running back won't be able to play after suffering a concussion last week. The Bills have also signed running back Dan Herron, and he could see some touches this Sunday. The Bills have a tough test without their top two backs, and quarterback Tyrod Taylor will likely need to carry their offense to get a win over the Titans Sunday.

The Redskins will be without two of their top weapons this weekend, and that could be a big issue as they face the third-highest scoring team in the league, the Atlanta Falcons. The Redskins have been without their top receiver Jackson since week one when he injured his hamstring against the Miami Dolphins.

Jackson is in his second season with the Redskins, and last year he caught 94 passes for 1,169 yards with six touchdowns. The Redskins could definitely have used Jackson against the Falcons, but they likely will also miss Reed just as much this weekend.

Reed suffered a concussion as well as a right MCL and ankle sprain last week against the Philadelphia Eagles. He has already caught 24 passes this season for 278 yards with a touchdown. With Reed out, tight end Derek Carrier will likely need to step up both in the pass game, and in his run blocking. The Redskins will surely have a tough test without both Jackson and Reed, and will likely need to dominate the time of possession by running the ball if they want to pull out a win over Atlanta.