For fans who have been praying to the sitcom Gods for a "Friends" reunion, Courteney Cox has some disappointing news for you.

According to the New York Daily News, the 49-year-old actress appeared on "The Late Show" with host David Letterman to discuss her directorial debut when the talk show presenter reluctantly brought up the topic of a possible reunion between the famous castmates.

"You're sick of the question, aren't you?" Letterman asked Cox.

Cox, who played Monica Geller on the show for 10 years, replied: "Only because once you say, 'Well, I'd like it,' then they have to contact every other cast member and be like, 'Courteney's into it!' And then I get in trouble... It's not gonna happen."

"Friends" aired for 10 seasons on NBC and starred Jennifer Aniston, Lisa Kudrow, Matt LeBlanc, Matthew Perry and David Schwimmer. The "Cougar Town" actress jokingly added that she has been unable to get all her co-stars together for a dinner, since the show ended in 2004.

"Let me tell you something, There's six friends and I have been trying to put together a cast dinner for 10 years," Cox told Letterman. "It doesn't happen. I mean, I can get the girls to come, maybe Matthew Perry. Matt LeBlanc canceled last time right at the last minute, [David] Schwimmer lives [in New York City], so it's just not going to happen."

Cox also shut down movie reunion rumors. The actress' comments reconfirm what series co-creator Marta Kauffman said last year about a "Friends" reunion.

"I'm going to clear this up -- it's not happening," Kauffman said at the time. "'Friends' was about that time in your life when your friends are your family and once you have a family, there's no need anymore."

In 2012, Aniston told The Hollywood Reporter that she was not interested in a reunion, stating: "I can't imagine what that would be. It's not normal. Friends is in your living room; Friends is not in a movie theater. It doesn't make sense to me. I think it would be going against its authentic self."