Madonna performed to a packed audience at London's O2 Arena on Tuesday night to kick off her "Rebel Heart Tour" in the United Kingdom.

The "Material Girl" rocked the arena, performing a series of old hits like "Like A Prayer" and new numbers from her "Rebel Heart" album, including "Living For Love."

The Queen of Pop performed her two-and-a-half-hour set with a dance troupe, donning a number of different costumes, and even treated the audience to a rock rendition of her 1983 hit "Burning Up," according to Reuters.

"Alright London, are you ready to blow this building up? It's good to be back where I belong," said the pop star, according to The Mirror. "I have a special fondness for this place."

In February, Madonna fell off the stage during her 2015 Brit Award performance after she was pulled backwards by her cape, as HNGN previously reported. However, this time, she finished the show without a hitch and the crowd roared with cheers and applause.

During her performance, Madonna was also joined onstage by Graham Norton, who gyrated with the singer while the two danced to "Unapologetic Bitch."

Madonna also took the opportunity to highlight World AIDS Day (Dec. 1). "The entire family of my adopted son died of AIDS", she said, referring to her son David, whom she took in from Malawi.

Watch some of the performances from Madonna's first night at the O2 Arena: