Warning! "Scream Queens" is going to be a bloodbath.

Show cocreator Ryan Murphy revealed a few secrets just ahead of the fall premiere, including who might make it to season two of the Fox horror-comedy anthology series.

[SPOILER ALERT] Murphy told the Hollywood Reporter that the show is going to kill off a bunch of characters and only four will return the next season—if the show gets renewed.

"It's similar to 'American Horror Story' in that it's anthological, but different in that, at the end of the first season, there will only be four characters out of 25 left and those four in season two will go on to a new horror genre—like a sorority is a horror genre to me," said Murphy about the upcoming season. "It's a place where there were horror movies in the '80s like 'Sorority Row,' and they will go on. That's the format of the show."

Good news: Unlike the "American Horror Story" series, the four surviving characters of "Scream Queens" will continue to play the same characters if the series in renewed for a second season.

"It's sort of like a twist on 'American Horror Story': every season is a new season, a new setting, a new establishment—the difference being you will know some of the characters who will live," added Murphy. "That's the fun to me—the reason I love writing it and being a part of it is it's like an Agatha Christie mystery where every week it's who's going to live and who's going to die. We do kill off a huge amount of people every week. It's a whodunit at its core.

"In the first episode, you've met the killer and there's a big clue dropped in the first episode as to who the killer is, so you'd have to go back and really watch it," said Murphy. "But we tell you who it is so you have to figure it out."

The first season of "Scream Queens" will star actress Emma Roberts as Chanel Oberlin, the president of the Kappa sorority, alongside Ariana Grande, Lea Michele, Keke Palmer, Billie Lourd, Nick Jonas and Abigail Breslin.

Murphy, who directed the first hour of the "Scream Queens" two-hour premiere, also revealed that veteran actress Jamie Lee Curtis agreed to do the show even before she read the script.

"I didn't know her and called her and said, 'I'm going to be frank with you, if you don't do the show, we're not doing it,'" recalled Murphy about his conversation with the actress. "We had no script, didn't have a deal with her and didn't even know her. We pitched this to her and she said she'd do it without reading a script."

"Scream Queens" premieres Tuesday, Sept. 22, on Fox.