More than 50 million people will be effected by the nor'easter headed toward the northeast.

The storm, which is headed from the midwest, is expected to reach the Mid-Atlantic region by Monday morning, bringing light to moderate snow from the eastern Ohio Valley to the I-95 corridor between Washington, D.C. to New York City, reported ABC News. 

The greatest impacts of the storm are expected to be Monday night through Tuesday. 

Over in Massachusetts the Massachusetts Emergency Management Agency (MEMA) is preparing for the two feet of snow forecasted to fall in some parts of the state. 

"All of the things that come into play during these events, we want to make sure there are no surprises and everybody is on the same page," MEMA spokesman Peter Judge said on Sunday.

On Sunday New York Mayor Bill de Blasio also warned residents to be prepared for a massive storm. 

"Prepare for something worse than we have seen before. Prepare to be safe. Take every precaution. Now is the time to get ready for this extreme weather," de Blasio said. "These are blizzard-type conditions. We expect easily two feet, even the potential of pressing on towards three feet." 

The storm is also expected to heavily hit the mid-Atlantic to New England, with blizzard watches posted for cities closer to the coast, including Boston, where blizzard conditions are expected during the height of the storm, reported ABC News.

As for travelers, United Airlines cancelled Tuesday flights at airports in New York, Boston and Philadelphia, due to winter weather warnings on the East Coast, a spokesperson said Sunday.

Other major airlines issued travel advisories, including Jet Blue, American, Southwest and Delta.