Katherine Heigl's Dr Izzie is set to make a comeback in "Grey's Anatomy" Season 13 while Marika Dominczyk will guest star in the next episode. ABC has also released the official plot summary for episode 5 titled, "Both Sides Now."

Rumor has it that Katherine Heigl will make a comeback in "Grey's Anatomy" Season 13. This is after Dr. Alexander Michael "Alex" Karev starts gaining more significance in the show.

Heigl plays the role of Dr. Izzie Stevens who happens to be the former wife of Dr. Alex. Such rumor stemmed since the Izzie-Alex storyline left a cliffhanger after the filing of divorce papers. With Izzie returning in the show, fans are wondering if they will get the closure they've been waiting for, Inquisitr reports.

Aside from that, "Brothers and Sisters" alum Marika Dominczyk has been tapped to guest star in the upcoming episode of "Grey's Anatomy" Season 13. According to Entertainment Weekly, the 36-year old Polish-American actress will play the role of Eliza Minnick.

No further details and information have been released about Marika's guest role in the show. However, it is speculated that she will be Arizona Robbins (Jessica Capshaw) new love interest.

Marika is the real life wife of another Shondaland series star Scott Foley of "Scandal". As for the official plot synopsis of episode 5, ABC Go notes, "Dr. Meredith Grey (Ellen Pompeo) and Dr. Miranda Bailey (Chandra Wilson) are at odds when both of their patients need a liver transplant.

Elsewhere, Dr. Owen Hunt (Kevin McKidd) seeks help from the other doctors when he is charged with babysitting baby Harriet (Vicki Lewis) for the day and Dr. Amelia Shepherd struggles with telling Owen some important news."

"Grey's Anatomy" Season 13 episode 5 is titled "Both Sides Now." The upcoming episode is scheduled to premiere on Thursday, October 20, 2016, at 8:00 p.m. first and exclusive on ABC Television Network.

"Grey's Anatomy" is an American medical drama television series created and written by Shonda Rhimes.